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AK1 / Adenylate kinase 1  Proteína

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    AK1 / Adenylate kinase 1 Resumen e información sobre la proteína

    AK1 / Adenylate kinase 1 Fondo

    Resumen de gen: Adenylate kinase is an enzyme involved in regulating the adenine nucleotide composition within a cell by catalyzing the reversible transfer of phosphate group among adinine nucleotides. Three isozymes of adenylate kinase have been identified in vertebrates, adenylate isozyme 1 (AK1), 2 (AK2) and 3 (AK3). AK1 is found in the cytosol of skeletal muscle, brain and erythrocytes, whereas AK2 and AK3 are found in the mitochondria of other tissues including liver and heart. AK1 was identified because of its association with a rare genetic disorder causing nonspherocytic hemolytic anemia where a mutation in the AK1 gene was found to reduce the catalytic activity of the enzyme.
    General information above from NCBI
    Actividad catalítica: ATP + AMP = 2 ADP.
    Estructura de subunidad: Monomer.
    Dominio: Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.
    Localización subcelular: Cytoplasm.
    Especificidad del tejido: Expressed in all tissues examined with highest expression in brain, lung, pancreas, and placenta. Expressed in cutaneous T-cell lymphomas (CTCL).
    Implicación en la enfermedad: Hemolytic anemia due to adenylate kinase deficiency (HAAKD) [MIM:612631]: A disease characterized by hemolytic anemia and undetectable erythrocyte adenylate kinase activity. Note=The disease is caused by mutations affecting the gene represented in this entry.
    Similitud de la secuencia: Belongs to the adenylate kinase family. AK1 subfamily.
    General information above from UniProt

    AK1 / Adenylate kinase 1 Nombre alternativo

    HTL-S-58j, [homo-sapiens]
    RP11-203J24.1, [human]
    Ak-1,B430205N08Rik,RP23-17P12.3, [mouse]
    Ak-1,B430205N08Rik, [mus-musculus]

    AK1 / Adenylate kinase 1 Estudios relacionados

  • Lu Q, et al. (1996) Adenylate kinase complements nucleoside diphosphate kinase deficiency in nucleotide metabolism. Proc Natl Acad Sci. 93 (12): 5720-5.
  • Dzeja P, et al. (2009) Adenylate kinase and AMP signaling networks: Metabolic monitoring, signal communication and body energy sensing. Int J Mol Sci. 10 (4): 1729-72.
  • Lagresle-Peyrou C, et al. (2008) Human adenylate kinase 2 deficiency causes a profound hematopoietic defect associated with sensorineural deafness. Nature Genetics. 41: 106 - 11.