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Protein HC/Bikunin  Proteína

All Bikunin Reagents

Anfitrión de expresión: Human Cells  
  • Slide 1
13141-H05H1-100
13141-H05H1-20
100 µg 
20 µg 
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Anfitrión de expresión: Yeast  
  • Slide 1
13141-H07Y-20
13141-H07Y-100
20 µg 
100 µg 
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Anfitrión de expresión: Human Cells  
  • Slide 1
13141-H08H1-20
13141-H08H1-100
20 µg 
100 µg 
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Anfitrión de expresión: Human Cells  
  • Slide 1
81299-R08H-20
81299-R08H-100
20 µg 
100 µg 
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Protein HC/Bikunin Resumen e información sobre la proteína

Protein HC/Bikunin Fondo

Estructura de subunidad: I-alpha-I plasma protease inhibitors are assembled from one or two heavy chains (H1, H2 or H3) and one light chain, bikunin. Inter-alpha-inhibitor (I-alpha-I) is composed of H1, H2 and bikunin, inter-alpha-like inhibitor (I-alpha-LI) of H2 and bikunin, and pre-alpha-inhibitor (P-alpha-I) of H3 and bikunin. Alpha-1-microglobulin occurs as a monomer and also in complexes with IgA and albumin. Alpha-1-microglobulin interacts with FN1. Trypstatin is a monomer and also occurs as a complex with tryptase in mast cells (By similarity). Alpha-1-microglobulin and bikunin interact (via SH3 domain) with HEV ORF3 protein.
Localización subcelular: Secreted.
Especificidad del tejido: Expressed by the liver and secreted in plasma. Alpha-1-microglobulin occurs in many physiological fluids including plasma, urine, and cerebrospinal fluid. Inter-alpha- trypsin inhibitor is present in plasma and urine.
Postranslacional: The precursor is proteolytically processed into separately functioning proteins.
3-hydroxykynurenine, an oxidized tryptophan metabolite that is common in biological fluids, reacts with Cys-53, Lys-111, Lys- 137, and Lys-149 to form heterogeneous polycyclic chromophores including hydroxanthommatin. The reaction by alpha-1-microglobulin is autocatalytic; the human protein forms chromophore even when expressed in insect and bacterial cells. The chromophore can react with accessible cysteines forming non-reducible thioether cross- links with other molecules of alpha-1-microglobulin or with other proteins such as Ig alpha-1 chain C region 'Cys-352'.
Heavy chains are interlinked with bikunin via a chondroitin 4-sulfate bridge to the their C-terminal aspartate (By similarity).
N- and O-glycosylated. N-glycan heterogeneity at Asn-115: Hex5HexNAc4 (major), Hex6HexNAc5 (minor) and dHex1Hex6HexNAc5 (minor). N-glycan at Asn-250: Hex5HexNAc4. O-linkage of the glycosaminoglycan, chondroitin sulfate, at Ser-215 allows cross- linking between the three polypeptide chains.
Similitud de la secuencia: In the N-terminal section; belongs to the calycin superfamily. Lipocalin family.
Contains 2 BPTI/Kunitz inhibitor domains.C
General information above from UniProt

Protein HC/Bikunin Nombre alternativo

A1M,HCP,ITI,UTI,EDC1,HI30,ITIL,IATIL,ITILC, [homo-sapiens]
alpha-1-microglobulin/bikunin precursor,AMBP,A1M,EDC1,HI30,IATIL,ITI,ITIL,ITILC,UTI,bikunin,complex-forming glycoprotein heterogeneous in charge,growth-inhibiting protein 19,inter-alpha-trypsin inhibitor light chain,protein AMBP,protein HC,trypstatin,uristatin,uronic-acid-rich protein,HCP, [human]
alpha 1 microglobulin/bikunin,Ambp,RP23-6H1.3,AI194774,ASPI,HI-30,Intin4,Itil,UTI,Urinary Trypsin Inhibitor,polyprotein,protein AMBP,ulinastatin, [mouse]
UTI,ASPI,Itil,HI-30,Intin4,AI194774, [mus-musculus]

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