About Us

Why Sino Biological Can Become a Leading Brand within 10 Years

Founded by MIT professor, Dr. Daniel I.C. Wang, and his former student, Dr. Liangzhi Xie, in 2007, Sino Biological Inc. is a developing biological reagents manufacturer located in Beijing, offering a comprehensive set of premium quality reagents, all of which are produced in-house and cover a broad range of life science research and drug development. It also provides one-stop services for protein and antibody discovery, research, development, production and commercialization. Meanwhile, Sino Biological is dedicated to research and development of biological pharmaceuticals. Our history...

Professional Team

• 400+ Research Staff & Growing
• 20+ Staff with US/EU Education
• 36% Staff with Master or PhD Degree More

Stringent Quality Control System

• 90+ Quality Control Staff
• Over 500 SOPs
• Examples of Comprehensive Lists of Protein Functional Assays More

Premium Biological Reagents & Services and Advanced Technology Platforms

Protein Technologies
Five Expression Systems,
Experience of 6,000+ Protein Production,
1,000+ Bio-activity Assays,
Validated Formulation Methods
Antibody Technologies
Antibody Library,
Rabbit Monoclonal Antibody,
Antibody Humanization,
Single Cell PCR
Gene Technologies
cDNA Library,
Gene Knock-out,
Expression-ready Vector,
Virus Technologies
Virus Vector,
Pseudo Virus,
Virus-like Particle,
Neutralizing Antibody
Cell Technologies
Animal Cells,
Yeast Cells,
Stem Cells,
Insect Cells, T Cells

What really differentiates Sino Biological

Bank of Recombinant Proteins

  • • 6,000+ Proteins in Stock
  • • 90% by Eukaryotic Cells
  • • Made All in House
  • • Multiple Species

Bank of Cytokines & Receptors

  • • 600+ Cytokines
  • • 500+ Cytokine Receptors
  • • Cover All Cytokine Families
  • • Over 12 Species
  • • All of the Popular Targets
  • • Validated Activities

Drug Target Reagents

  • • 5,000+ Drug Target Reagents
  • • Multiple Therapeutic Areas
  • • A Wide Range of Reagents in Immune Checkpoint Research

Monoclonal Antibody Tools

  • • Maximum 200-Fold Enhanced ELISA Sensitivity
  • • 5 pg-level Antigen Detection Limit in Western Blot
  • • Leading 2nd Generation Rabbit MAb Technology

Centralized Protein & Antibody Expression Lab Worldwide

  • • 60+ Highly Centralized Cell Culture Bioreactors
  • • 2,000+ New Proteins & Antibodies per Year
  • • 30-100 Grams Custom-tailored MAb Production in Weeks

Leading Pre-Clinical CRO for Biologics

  • • Sweeping Service from Discovery to Production
  • • Record Speed from DNA to Purified MAbs
  • • Serving Well-known Pharmaceutical/Biotech Companies

What Sino Biological Offers

1. Premium Reagents

• 100% Made in House
• ISO9001-2008 (GB / T19001-2008) Quality Management System Certification
• State-of-the-art Analytical Equipment Set to Ensure Validated Function

6,000+ Proteins
• In Stock
• 90% Expressed in Eukaryotic Cells
• Adequate Inventory
10,000+ Antibodies
• Classical Mouse MAb Technology
• 2nd Gen. Rabbit MAb Technology

800+ ELISA Kits/Pair Sets
• Large Human Serum Sample Pools
• Stability Testing
• High Sensitivity

400,000+ Genes
• cDNA Clones & Expression-ready ORF
• Multiple Species & Hot Research Fields
• Full-length Sequenced

Serum Free Expression Media
• Animal Free, Stable Performance
• Easy to Be Produced Massively
• Suitable for High-Density Culture of HEK293, CHO, Hi5, SF9, SF21, and MAb, Viral Antigen and Recombinant Protein Production, etc.

2. Superior CRO Services

Molecular Biology Services
• Gene Synthesis & Cloning, Vector Construction, Plasmid Production
• Antibody Sequencing
• Real Time PCR Primer and Probe Design , qPCR / pRT-PCR Analysis
• CRISPR-CAS9 Knockout Cell Line Generation
Protein Production Services
• Mammalian Expression: Transient Expression, Stable CHO Cell Expression
• Baculovirus Insect Cell Expression
• Yeast Expression
• E.Coli Expression

Antibody Development and Production Services
• Rabbit PAb Services
• Rabbit/ Mouse MAb Production Service
• ScFv/Fab Antibody Fragment Production
• Antibody Transient Expression
• Antibody Purification
• Antibody Humanization Engineering CRO Services
Analytical Services
• Biochemical Characterization
• Biophysical Characterization
• Biological Activity Assays

Transient Transfection CRO Services
• Transient Transfection in HEK293 Cells, CHO Cells
• Transient Transfection Services for Protein and Antibody Production

Services for Pharmaceutical Drug Development
• Therapeutic Antibody Generation, Humanization and Affinity Maturation
• Cell Line Engineering, Cell Banking
• Process Development, Assay Development, Formulation Development
• GMP production

How Good the Reagents Are

Title PMID Year Authors Journal Official Name Catalogue Application
TGFβ drives immune evasion in genetically reconstituted colon cancer metastasis 29443964 2018 Tauriello, DVF; et al. et al. Nature CD4 50134-R001 IHC
Structure of the human PKD1/PKD2 complex   2018 Su, Q; et al. et al. Science   SMM 293T-I Cell culture
Structure of the human voltage-gated sodium channel Nav1.4 in complex with β1 30190309 2018 Pan, X;Li, Z; et al. et al. Science   SMM 293T-I Cell culture
Cryo-EM Structure of Human Dicer and Its Complexes with a Pre-miRNA Substrate 29856959 2018 Liu, Z; et al. et al. Cell   SMM 293-TI Cell culture
Selective FcγR Co-engagement on APCs Modulates the Activity of Therapeutic Antibodies Targeting T Cell Antigens 29894690 2018 Waight, JD; et al. et al. Cancer Cell CTLA4 11159-H08H SPR
Non-conventional Inhibitory CD4+Foxp3-PD-1hi T Cells as a Biomarker of Immune Checkpoint Blockade Activity 29894689 2018 Zappasodi, R; et al. et al. Cancer Cell PDCD1 50124-RP02 IF
A modular platform for targeted RNAi therapeutics 29379205 2018 Kedmi, R; et al. et al. Nat Nanotechnol CD34 50589-M08H ELISA
NKILA lncRNA promotes tumor immune evasion by sensitizing T cells to activation-induced cell death   2018 Huang, D; et al. et al. Nat. Immunol. RELA 12054-H09E Binding (RNA)
A multifunctional human monoclonal neutralizing antibody that targets a unique conserved epitope on influenza HA 29991715 2018 Bangaru, S; et al. et al. Nat Commun HA 40149-V08B ELISA
TNF blockade induces a dysregulated type I interferon response without autoimmunity in paradoxical psoriasis   2018 Conrad, C; et al. et al. Nat Commun LAMP3 10527-RP02 IHC
Structure and evolution of the Fam20 kinases 29572475 2018 Zhang, H; et al. et al. Nat Commun   SIM SF Culture
Oxidation of Atg3 and Atg7 mediates inhibition of autophagy 29311554 2018 Frudd, K; et al. et al. Nat Commun ATG7 HG15684-UT Expression
Dual-functional peptide with defective interfering genes effectively protects mice against avian and seasonal influenza 29907765 2018 Zhao, H;To, KKW; et al. et al. Nat Commun HA 11055-RP02 WB
Neuronal SphK1 acetylates COX2 and contributes to pathogenesis in a model of Alzheimer's Disease 29662056 2018 Lee, JY; et al. et al. Nat Commun PTGS2 HG12036-NH Expression
The tyrosine phosphatase SHP2 controls TGFβ-induced STAT3 signaling to regulate fibroblast activation and fibrosis 30108215 2018 Zehender, A; et al. et al. Nat Commun JAK2 HG11198-NF Expression
Clptm1 Limits Forward Trafficking of GABA A  Receptors to Scale Inhibitory Synaptic Strength 29395912 2018 Ge, Y; et al. et al. Neuron GABRA4 HG14855-NY Expression
TREM2 Is a Receptor for β-Amyloid that Mediates Microglial Function 29518356 2018 Zhao, Y; et al. et al. Neuron TREM2 11084-H08H Octet
Th17 Lymphocytes Induce Neuronal Cell Death in a Human iPSC-Based Model of Parkinson's Disease 29979986 2018 Sommer, A; et al. et al. Cell Stem Cell IL17A 12047-M237 Cell-based
Fasting Activates Fatty Acid Oxidation to Enhance Intestinal Stem Cell Function during Homeostasis and Aging 29727683 2018 Mihaylova, MM; et al. et al. Cell Stem Cell RSPO1 50316-M08S Cell-based