Anti-CSF1R Antibody

Cat: 10161-RP02

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Anti-CSF1R Antibody (Rabbit Polyclonal antibody) General Information

Product name
Anti-CSF1R Antibody
Applications
ELISA,IHC-P
Species reactivity
Reacts with: Human
Specificity
Human CSF1R
Immunogen
Recombinant Human CSF1R / M-CSFR / CD115 protein (Catalog#10161-H20B2)
Preparation
Produced in rabbits immunized with purified, recombinant Human CSF1R / M-CSFR / CD115 (rh CSF1R / M-CSFR / CD115; Catalog#10161-H20B2; NP_005202.2; Lys543-Asp922). CSF1R / M-CSFR / CD115 specific IgG was purified by Human CSF1R / M-CSFR / CD115 affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A & Antigen Affinity
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-CSF1R Antibody (Rabbit Polyclonal antibody) Validated Applications

Application Dilution Notes
ELISA 1:5000-1:10000  
IHC-P 1:500-1:2000  

**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********

Anti-CSF1R Antibody (Rabbit Polyclonal antibody) Images

Human MCSF Receptor/CSF1R/CD115 Immunohistochemistry(IHC) 4346
Immunochemical staining of human CSF1R in human lung with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections).
Human MCSF Receptor/CSF1R/CD115 Immunohistochemistry(IHC) 4347
Immunochemical staining of human CSF1R in human kidney with rabbit polyclonal antibody (1:1000, formalin-fixed paraffin embedded sections).

Anti-CSF1R Antibody Alternative Names

Anti-C-FMS Antibody;Anti-CD115 Antibody;Anti-CSF-1R Antibody;Anti-CSFR Antibody;Anti-FIM2 Antibody;Anti-FMS Antibody;Anti-HDLS Antibody;Anti-M-CSF-R Antibody;Anti-MCSF Receptor Antibody

CSF1R Background Information

M-CSFR encoded by the proto-oncogene c-fms is the receptor for colony stimulating factor 1 (CSF1R), a cytokine involved in the proliferation, differentiation, and activation of macrophages. This cell surface glycoprotein is consisted by an extracellular ligand-binding domain, a single membrane-spanning segment, and an intracellular tyrosine kinase domain. Binding of CSF1 activates the receptor kinase, leading to "autophosphorylation" of receptor subunits and the concomitant phosphorylation of a series of cellular proteins on tyrosine residues. CSF1R is a tyrosine kinase receptor that is absolutely required for macrophage differentiation and thus occupies a central role in hematopoiesis. CSF1 and its receptor (CSF1R, product of c-fms proto-oncogene) were initially implicated as essential for normal monocyte development as well as for trophoblastic implantation. This apparent role for CSF1/CSF1R in normal mammary gland development is very intriguing because this receptor/ligand pair has also been found to be important in the biology of breast cancer in which abnormal expression of CSF1 and its receptor correlates with tumor cell invasiveness and adverse clinical prognosis. Tumor cell expression of CSF1R is under the control of several steroid hormones (glucocorticoids and progestins) and the binding of several bHLH transcription factors, while tumor cell expression of CSF-1 appears to be regulated by other hormones, some of which are involved in normal lactogenic differentiation. However, studies have demonstrated that CSF1 and CSF1R have additional roles in mammary gland development during pregnancy and lactation. The role of CSF1 and CSF1R in normal and neoplastic mammary development that may elucidate potential relationships of growth factor-induced biological changes in the breast during pregnancy and tumor progression.
Full Name
colony stimulating factor 1 receptor
References
  • Sherr CJ. (1990) The colony-stimulating factor 1 receptor: pleiotropy of signal-response coupling. Lymphokine Res. 9(4): 543-8.
  • Kacinski BM. (1997) CSF-1 and its receptor in breast carcinomas and neoplasms of the female reproductive tract. Mol Reprod Dev. 46(1): 71-4.
  • Sapi E, et al. (1999) The role of CSF-1 in normal and neoplastic breast physiology. Proc Soc Exp Biol Med. 220(1): 1-8.
  • Sapi E. (2004) The role of CSF-1 in normal physiology of mammary gland and breast cancer: an update. Exp Biol Med (Maywood). 229(1): 1-11.
  • Bonifer C, et al. (2008) The transcriptional regulation of the Colony-Stimulating Factor 1 Receptor (csf1r) gene during hematopoiesis. Front Biosci. 13: 549-60.
  • Product Description Host Clonality Application Catalog# (PDF)
    Anti-CSF1R Antibody Rabbit Polyclonal ELISA 80447-RP01
    Anti-CSF1R Antibody Rabbit Polyclonal ELISA 80447-T16
    Anti-CSF1R Antibody Rabbit Monoclonal ELISA 50059-R220
    Anti-CSF1R Antibody Rabbit Polyclonal ELISA 50059-RP02
    Anti-CSF1R Antibody Rabbit Polyclonal ELISA 50059-T16
    Anti-CSF1R Antibody Rabbit Polyclonal WB,ELISA 50059-RP01
    Anti-CSF1R Antibody Rabbit Polyclonal ELISA,IHC-P 50059-T24
    Anti-CSF1R Antibody Mouse Monoclonal ELISA 10161-MM12
    Anti-CSF1R Antibody Rabbit Polyclonal ELISA 10161-RP01
    Anti-CSF1R Antibody Rabbit Monoclonal ELISA 10161-R029
    Anti-CSF1R Antibody Rabbit Polyclonal ELISA 10161-RP03
    Anti-CSF1R Antibody Rabbit Polyclonal ELISA,IHC-P 10161-T24
    Anti-CSF1R Antibody Rabbit Monoclonal ELISA 10161-R108
    Anti-CSF1R Antibody (FITC) Mouse Monoclonal FCM 10161-MM04-F
    Anti-CSF1R Antibody Mouse Monoclonal FCM 10161-MM04
    Anti-CSF1R Antibody Mouse Monoclonal ELISA 10161-MM02
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