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Endoglin / CD105 / ENG Antibody, Rabbit PAb, Antigen Affinity Purified

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Human ENG Información de producto de anticuerpo
Inmunogen:A synthetic peptide corresponding to the N-terminus of the Human CD105.
Clone ID:
Tipo de Ig:Rabbit IgG
Concentración:
Endotoxina:
Formulación:0.2 μm filtered solution in PBS with 5% trehalose
Preparación:Produced in rabbits immunized with a synthetic peptide corresponding to the N-terminus of the Human CD105, and purified by antigen affinity chromatography.
Human ENG Guía de uso de anticuerpo
Especificidad:Human CD105
Aplicación:WB, IHC-P

WB: 1-2 μg/mL

IHC-P: 0.1-2 μg/mL

Almacenamiento:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Human ENG Antibody WB Application Image
Endoglin / CD105 / ENG Antibody, Rabbit PAb, Antigen Affinity Purified, Western blot
Human ENG Antibody IHC Application Image
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Caption:
Immunochemical staining of human CD105 in human kidney with rabbit polyclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections). Positive staining was localized to endothelial cells.
Endoglin / CD105 / ENG Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
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Caption:
Immunochemical staining of human CD105 in human lung with rabbit polyclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections). Positive staining was localized to endothelial cells.
Endoglin / CD105 / ENG Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
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Caption:
Immunochemical staining of human CD105 in human tonsil with rabbit polyclonal antibody (1 µg/mL, formalin-fixed paraffin embedded sections). Positive staining was localized to endothelial cells.
Endoglin / CD105 / ENG Antibody, Rabbit PAb, Antigen Affinity Purified, Immunohistochemistry
Other ENG Antibody Products
Endoglin/CD105  Fondo

Endoglin, also known as CD105, is a type I  homodimeric transmembrane glycoprotein with a large, disulfide-linked, extracellular region and a short, constitutively phosphorylated cytoplasmic tail. Endoglin contains an RGD tripeptide which is a key recognition structure in cellular adhesion,,suggesting a critical role for endoglin in the binding of endothelial cells to integrins and/or other RGD receptors. Endoglin is highly expressed on vascular endothelial cells, chondrocytes, and syncytiotrophoblasts of term placenta. It is also found on activated monocytes, mesenchymal stem cells and leukemic cells of lymphoid and myeloid lineages. As an accessory receptor for the TGF-β superfamily ligands, endoglin binds TGF-β1 and TGF-β3 with high affinity not by itself but by associating with TGF-β type I I receptor (TβRII) and activates the downstream signal pathways. In addition, in human umbilical vein endothelial cells, ALK-1 is also a receptor kinase for endoglin threonine phosphorylation, and mutations in either of the two genes result in the autosomal-dominant vascular dysplasia, hereditary hemorrhagic telangiectasia (HHT). Endoglin has been regarded as a powerful biomarker of neovascularization, and is associated with several solid tumor types.

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