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Humano CD131/CSF2RB/IL3RB/IL5RB clonación del ADN o clonación génica(vector de clonación), N-HA Etiqueta

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Human CSF2RB Información de producto de clon de cDNA
Gene_bank_ref_id:NM_000395.2
Tamaño de cDNA:2694bp
Descripción de cDNA:Full length Clone DNA of Homo sapiens colony stimulating factor 2 receptor, beta, low-affinity (granulocyte-macrophage) with N terminal HA tag.
Sinónimo de gen:CD131, IL3RB, IL5RB, CDw131
Especie:Human
Vector:pCMV3-SP-N-HA
Plasmid:
Sitio de restricción:
Secuencia de etiquetas:HA Tag Sequence: TATCCTTACGACGTGCCTGACTACGCC
Descripción de la secuencia:
Sequencing primers:T7(TAATACGACTCACTATAGGG) BGH(TAGAAGGCACAGTCGAGG)
Promoter:Enhanced CMV mammalian cell promoter
Application:Stable or Transient mammalian expression
Antibiotic in E.coli:Kanamycin
Antibiotic in mammalian cell:Hygromycin
Shipping_carrier:Each tube contains lyophilized plasmid.
Almacenamiento:The lyophilized plasmid can be stored at room temperature for three months.
HA Tag Info

Human influenza hemagglutinin (HA) is a surface glycoprotein required for the infectivity of the human virus. The HA tag is derived from the HA-molecule corresponding to amino acids 98-106 has been extensively used as a general epitope tag in expression vectors. Many recombinant proteins have been engineered to express the HA tag, which does not appear to interfere with the bioactivity or the biodistribution of the recombinant protein. This tag facilitates the detection, isolation, and purification of the proteins.

The actual HA tag is as follows: 5' TAC CCA TAC GAT GTT CCA GAT TAC GCT 3' or 5' TAT CCA TAT GAT GTT CCA GAT TAT GCT 3' The amino acid sequence is: YPYDVPDYA.

Humano CD131/CSF2RB/IL3RB/IL5RB clonación del ADN o clonación génica(vector de clonación), N-HA Etiqueta on other vectors
Humano CD131/CSF2RB/IL3RB/IL5RB clonación del ADN o clonación génica(vector de clonación), C-GFPSpark EtiquetaHG10516-ACG$325
Humano CD131/CSF2RB/IL3RB/IL5RB clonación del ADN o clonación génica(vector de clonación), C-OFPSpark EtiquetaHG10516-ACR$325
Humano CD131/CSF2RB/IL3RB/IL5RB clonación del ADN o clonación génica(vector de clonación), C-Flag EtiquetaHG10516-CF$295
Humano CD131/CSF2RB/IL3RB/IL5RB clonación del ADN o clonación génica(vector de clonación), C-His EtiquetaHG10516-CH$295
Humano CD131/CSF2RB/IL3RB/IL5RB clonación del ADN o clonación génica(vector de clonación), C-Myc EtiquetaHG10516-CM$295
Humano CD131/CSF2RB/IL3RB/IL5RB clonación del ADN o clonación génica(vector de clonación), C-HA EtiquetaHG10516-CY$295
Humano CD131/CSF2RB/IL3RB/IL5RB clonación del ADN o clonación génica(Vector de expresión)HG10516-M$75
Humano CD131/CSF2RB/IL3RB/IL5RB clonación del ADN o clonación génica(vector de clonación), N-Flag EtiquetaHG10516-NF$295
Humano CD131/CSF2RB/IL3RB/IL5RB clonación del ADN o clonación génica(vector de clonación), N-His EtiquetaHG10516-NH$295
Humano CD131/CSF2RB/IL3RB/IL5RB clonación del ADN o clonación génica(vector de clonación), N-Myc EtiquetaHG10516-NM$295
Humano CD131/CSF2RB/IL3RB/IL5RB clonación del ADN o clonación génica(vector de clonación), N-HA EtiquetaHG10516-NY$295
Humano CD131/CSF2RB/IL3RB/IL5RB clonación del ADN o clonación génica(vector de clonación)HG10516-UT$295
 Más información sobre los vectores de expresión
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Fondo

Colony stimulating factor 2 receptor, beta, low-affinity (CSF2RB) also known as CD131 antigen (CD131), cytokine receptor common subunit beta, GM-CSF/IL-3/IL-5 receptor common beta-chain, interleukin 3 receptor/granulocyte-macrophage colony stimulating factor 3 receptor, beta (IL3RB), is the common beta chain of the high affinity receptor for IL-3, IL-5 and CSF. Defects in this protein have been reported to be associated with protein alveolar proteinosis (PAP). CD131 belongs to the type I cytokine receptor family. The cluster of differentiation (cluster of designation) (often abbreviated as CD) is a protocol used for the identification and investigation of cell surface molecules present on white blood cells initially but found in almost any kind of cell of the body, providing targets for immunophenotyping of cells. Defects in CD131/CSF2RB are the cause of pulmonary surfactant metabolism dysfunction type 5 (SMDP5). SMDP5 is a rare lung disorder due to impaired surfactant homeostasis. It is characterized by alveolar filling with floccular material that stains positive using the periodic acid-Schiff method and is derived from surfactant phospholipids and protein components. Excessive lipoproteins accumulation in the alveoli results in severe respiratory distress.

Referencias
  • Selleri S, et al. (2008) GM-CSF/IL-3/IL-5 receptor common beta chain (CD131) expression as a biomarker of antigen-stimulated CD8+ T cells. J Transl Med. 6:17.
  • Woodcock, et al. (1994) Three residues in the common beta chain of the human GM-CSF, IL-3 and IL-5 receptors are essential for GM-CSF and IL-5 but not IL-3 high affinity binding and interact with Glu21 of GM-CSF. EMBO J. 13(21): 5176-85.
  • Dirksen U, et al. (1997) Human pulmonary alveolar proteinosis associated with a defect in GM-CSF/IL-3/IL-5 receptor common beta chain expression. J Clin Invest. 100(9): 2211-7.
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