IGF1R qPCR Primer Pairs, Human

Cat: HP100036
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IGF1R qPCR Primer Pairs, Human General Information
Target Details
Species:
Human
NCBI RefSeq:
PCR Size:
117bp
Product Details
Oligo-Type:
qPCR Primers
Component:
1 vial of lyophilized qPCR primer mix (1 nmol each primer, sufficient for 200 numbers of 25 μl reactions).
QPCR Primer Description:
Verified forward and reverse primers for analyzing the quantitative expression of gene.
Application & Quality
Application:
SYBR® Green-based quantitative real-time PCR (qPCR).
Quality Control:
The primer mix has been verified to generate satisfactory qPCR data on Roche Applied-science LightCycler® 480 Ⅱ.
Storage & Shipping
Shipping:
Lyophilized qPCR primer mix is shipped at ambiente temperatura
Storage:
The lyophilized product is stable for one year from date of receipt when stored at -20℃. The suspended product is stable for six months from date of receipt when stored at -20℃.

***Sino biological qEASY qPCR primer pairs are used for SYBR Green-based real-time RT-PCR, The primers are designed by using SBI's proprietary primer design algorithm. Our primer collection covers the entire human genomes. It can be widely applied in the quantitative analysis of gene expression.***

Features and Advantages
Unique Primer Design
To avoid genomic DNA amplification, at least one primer is designed crosses the junction of exons according to the conserved region of a specific gene with all variants.
Strict Validation Process
Confirmed in positive organizations; screened the primer with high specificity and high sensitivity.
Uniform PCR conditions, Saving time and cost
~100% amplification curve, ensuring the accuracy of the RNA quantitative
IGF1R qPCR Primer Pairs, Human Validated Images
Human IGF1R/CD221/IGF-I R qPCR 4819
IGF1R dissolution curves
Human IGF1R/CD221/IGF-I R qPCR 4820
IGF1R amplification curves
IGF1R qPCR Primer Pairs, Human Alternative Names
CD221 qPCR Primer Pairs, Human;IGF-I R qPCR Primer Pairs, Human;IGF1 Receptor qPCR Primer Pairs, Human;IGFIR qPCR Primer Pairs, Human;IGFR qPCR Primer Pairs, Human;JTK13 qPCR Primer Pairs, Human
IGF1R Background Information

The insulin-like growth factor-1 receptor (IGF1R) is a transmembrane tyrosine kinase involved in several biological processes including cell proliferation, differentiation, DNA repair, and cell survival. This a disulfide-linked heterotetrameric transmembrane protein consisting of two α and two β subunits, and among which, the α subunit is extracellular while the β subunit has an extracellular domain, a transmembrane domain and a cytoplasmic tyrosine kinase domain. IGF1R signalling pathway is activated in the mammalian nervous system from early developmental stages. Its major effect on developing neural cells is to promote their growth and survival. This pathway can integrate its action with signalling pathways of growth and morphogenetic factors that induce cell fate specification and selective expansion of specified neural cell subsets. Modulation of cell migration is another possible role that IGF1R activation may play in neurogenesis. In the mature brain, IGF-I binding sites have been found in different regions of the brain, and multiple reports confirmed a strong neuroprotective action of the IGF-IR against different pro-apoptotic insults. IGF1R is an important signaling molecule in cancer cells and plays an essential role in the establishment and maintenance of the transformed phenotype. Inhibition of IGF1R signaling thus appears to be a promising strategy to interfere with the growth and survival of cancer cells. IGF1R is frequently overexpressed by tumours, and mediates proliferation and apoptosis protection. IGF signalling also influences hypoxia signalling, protease secretion, tumour cell motility and adhesion, and thus can affect the propensity for invasion and metastasis. Therefore, the IGF1R is now an attractive anti-cancer treatment target.

Immune Checkpoint   Immunotherapy   Cancer Immunotherapy   Targeted Therapy

Full Name
insulin-like growth factor 1 receptor
References
  • Bhr C, et al. (2004) The insulin like growth factor-1 receptor (IGF-1R) as a drug target: novel approaches to cancer therapy. Growth Horm IGF Res. 14 (4): 287-95.
  • Riedemann J, et al. (2006) IGF1R signalling and its inhibition. Endocr Relat Cancer. 13 Suppl 1: 33-43.
  • Gualco E, et al. (2009) IGF-IR in neuroprotection and brain tumors. Front Biosci. 14: 352-75.
  • Annenkov A. (2009) The insulin-like growth factor (IGF) receptor type 1 (IGF1R) as an essential component of the signalling network regulating neurogenesis. Mol Neurobiol. 40 (3): 195-215.
  • IGF1R qPCR Primer Pairs, Canine, Related Products

    Product Name Catalog#(PDF)
    IGF1R cDNA ORF Clone in Cloning Vector, Canine DG70098-G
    IGF1R cDNA ORF Clone, Canine, untagged DG70098-UT
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    IGF1R cDNA ORF Clone, Canine, C-His tag DG70098-CH
    IGF1R cDNA ORF Clone, Canine, N-His tag DG70098-NH
    IGF1R cDNA ORF Clone, Canine, C-HA tag DG70098-CY
    IGF1R cDNA ORF Clone, Canine, N-HA tag DG70098-NY
    IGF1R cDNA ORF Clone, Canine, C-Myc tag DG70098-CM
    IGF1R cDNA ORF Clone, Canine, N-Myc tag DG70098-NM

    IGF1R qPCR Primer Pairs, Rhesus, Related Products

    Product Name Catalog#(PDF)
    IGF1R cDNA ORF Clone in Cloning Vector, Rhesus CG90082-G
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    IGF1R Lentiviral cDNA ORF Clone, Rhesus, C-GFPSpark® tag CG90082-ACGLN
    IGF1R cDNA ORF Clone, Rhesus, C-GFPSpark® tag CG90082-ACG
    IGF1R cDNA ORF Clone, Rhesus, C-OFPSpark® tag CG90082-ACR
    IGF1R cDNA ORF Clone, Rhesus, C-DDK (Flag®) tag CG90082-CF
    IGF1R cDNA ORF Clone, Rhesus, N-DDK (Flag®) tag CG90082-NF
    IGF1R cDNA ORF Clone, Rhesus, C-His tag CG90082-CH
    IGF1R cDNA ORF Clone, Rhesus, N-His tag CG90082-NH
    IGF1R cDNA ORF Clone, Rhesus, C-HA tag CG90082-CY
    IGF1R cDNA ORF Clone, Rhesus, N-HA tag CG90082-NY
    IGF1R cDNA ORF Clone, Rhesus, C-Myc tag CG90082-CM
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    IGF1R qPCR Primer Pairs, Human, Related Products

    Product Name Catalog#(PDF)
    IGF1R cDNA ORF Clone in Cloning Vector, Human HG10164-M
    IGF1R cDNA ORF Clone, Human, untagged HG10164-UT
    IGF1R Lentiviral cDNA ORF Clone, Human, C-GFPSpark® tag HG10164-ACGLN
    IGF1R cDNA ORF Clone, Human, C-GFPSpark® tag HG10164-ACG
    IGF1R cDNA ORF Clone, Human, C-OFPSpark® tag HG10164-ACR
    IGF1R cDNA ORF Clone, Human, C-DDK (Flag®) tag HG10164-CF
    IGF1R cDNA ORF Clone, Human, N-DDK (Flag®) tag HG10164-NF
    IGF1R cDNA ORF Clone, Human, C-His tag HG10164-CH
    IGF1R cDNA ORF Clone, Human, N-His tag HG10164-NH
    IGF1R cDNA ORF Clone, Human, C-HA tag HG10164-CY
    IGF1R cDNA ORF Clone, Human, N-HA tag HG10164-NY
    IGF1R cDNA ORF Clone, Human, C-Myc tag HG10164-CM
    IGF1R cDNA ORF Clone, Human, N-Myc tag HG10164-NM
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