Syndecan-1 cDNA ORF Clone, Human, N-Myc tag General Information
Identical with the Gene Bank Ref. ID sequence except for the point mutations: 279G/A not causing the amino acid variation.
Full length Clone DNA of Human syndecan 11 with N terminal Myc tag.
Enhanced CMV promoter
KpnI + XbaI (6kb + 0.96kb)
Myc Tag Sequence: GAGCAGAAACTCATCTCAGAAGAGGATCTG
T7( 5' TAATACGACTCACTATAGGG 3' )
BGH( 5' TAGAAGGCACAGTCGAGG 3' )
The plasmid is confirmed by full-length sequencing.
Antibiotic in E.coli
Antibiotic in Mammalian cell
Stable or Transient mammalian expression
Storage & Shipping
Each tube contains lyophilized plasmid.
The lyophilized plasmid can be stored at ambient temperature for three months.
**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**
Syndecan-1 cDNA ORF Clone, Human, N-Myc tag Validated Images
Syndecan-1 cDNA ORF Clone, Human, N-Myc tag Alternative Names
CD138 cDNA ORF Clone, Human;SDC cDNA ORF Clone, Human;SYND1 cDNA ORF Clone, Human;syndecan cDNA ORF Clone, Human;Syndecan-1 cDNA ORF Clone, Human
Syndecan-1 Background Information
Syndecan-1 also known as SDC1 and CD138, is the most extensively studied member of the syndecan family. It is found mainly in epithelial cells, but its expression is developmentally regulated during embryonic development. Syndecan-1/SDC1/CD138 has been shown to mediate cell adhesion to several ECM molecules, and to act as a coreceptor for fibroblast growth factors, potent angiogenic growth factors involved also in differentiation. Syndecan-1/SDC1/CD138 expression is reduced during malignant transformation of various epithelia, and this loss correlates with the histological differentiation grade of squamous cell carcinomas, lacking from poorly differentiated tumours. In squamous cell carcinomas of the head and neck, positive syndecan-1 expression correlates with a more favourable prognosis. Experimental studies on the role of Syndecan-1 in malignant transformation have shown that Syndecan-1/SDC1/CD138 expression is associated with the maintenance of epithelial morphology, anchorage-dependent growth and inhibition of invasiveness in vitro.
Inki P, et al. (1996) The role of syndecan-1 in malignancies. Ann Med. 28(1): 63-7.Subramanian SV, et al. (1997) Regulated shedding of syndecan-1 and -4 ectodomains by thrombin and growth factor receptor activation. J Biol Chem. 272(23): 14713-20.Park PW, et al. (2001) Exploitation of syndecan-1 shedding by Pseudomonas aeruginosa enhances virulence. Nature. 411(6833): 98-102.