Pedido rápido

IL10RB / IL10R2 Anticuerpo, Pabs de conejo, Purificación por afinidad con antígenos

    Hoja de datosReseñasProductos relacionadosProtocolos
    Ratón IL10RB Información de producto de anticuerpo
    Inmunogen:Recombinant Mouse IL10RB / IL10R2 protein (Catalog#50846-M08H)
    Clone ID:
    Tipo de Ig:Rabbit IgG
    Concentración:
    Endotoxina:
    Formulación:0.2 μm filtered solution in PBS with 5% trehalose
    Preparación:Produced in rabbits immunized with purified, recombinant Mouse IL10RB / IL10R2 (rM IL10RB / IL10R2; Catalog#50846-M08H; NP_032375.2; Met 1-Ser 222). IL10RB / IL10R2 specific IgG was purified by Mouse IL10RB / IL10R2 affinity chromatography.
    Other IL10RB Antibody Products
    IL10RB / IL-10RB Fondo

    Interleukin 10 receptor, beta subunit (IL10RB/IL-10RB) also known as Cytokine receptor family 2 member 4, Interleukin-10 receptor subunit 2, and cytokine receptor family II, member 4, is a subunit for the interleukin-10 receptor. IL10RB/IL-10RB belongs to the cytokine receptor family. It is an accessory chain essential for the active interleukin 10 receptor complex. Coexpression of this and IL10RA proteins has been shown to be required for IL10-induced signal transduction. Defects in IL10RB/IL-10RB are the cause of inflammatory bowel disease type 25 (IBD25). It is a chronic, relapsing inflammation of the gastrointestinal tract with a complex etiology. It is subdivided into Crohn disease and ulcerative colitis phenotypes. Crohn disease may affect any part of the gastrointestinal tract from the mouth to the anus, but most frequently it involves the terminal ileum and colon. Bowel inflammation is transmural and discontinuous; it may contain granulomas or be associated with intestinal or perianal fistulas. In contrast, in ulcerative colitis, the inflammation is continuous and limited to rectal and colonic mucosal layers; fistulas and granulomas are not observed. Both diseases include extraintestinal inflammation of the skin, eyes, or joints.

    Ratón IL10RB / IL-10RB Referencias
  • Josephson K, et al. (2001) Crystal structure of the IL-10/IL-10R1 complex reveals a shared receptor binding site. Immunity. 15 (1): 35-46.
  • Yoo KH, et al. (2011) Association of IL10, IL10RA, and IL10RB polymorphisms with benign prostate hyperplasia in Korean population. J Korean Med Sci. 26(5): 659-64.
  • Product nameProduct name
    All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
    Nota: Todos los productos son "PARA SU USO ÚNICAMENTE EN INVESTIGACIÓN Y NO INDICADOS PARA SU USO DIAGNÓSTICO O TERAPÉUTICO"