Pedido rápido

IL1F6 / IL36A Anticuerpo, Pabs de conejo

Hoja de datosReseñasProductos relacionadosProtocolos
Human IL1F6 Información de producto de anticuerpo
Inmunogen:Recombinant Human IL1F6 / IL36A protein (Catalog#10607-HNAE)
Clone ID:
Tipo de Ig:Rabbit IgG
Concentración:
Formulación:0.2 μm filtered solution in PBS with 5% trehalose
Preparación:Produced in rabbits immunized with purified, recombinant Human IL1F6 / IL36A (rh IL1F6 / IL36A; Catalog#10607-HNAE; Q9UHA7; Met 1-Phe 158). Total IgG was purified by Protein A affinity chromatography.
Human IL1F6 Guía de uso de anticuerpo
Especificidad:Human IL1F6 / IL36A
Aplicación:ELISA

ELISA: 0.5-1 μg/mL

This antibody can be used at 0.5-1 μg/mL with the appropriate secondary reagents to detect Human IL1F6. The detection limit for Human IL1F6 is approximately 0.00975 ng/well.

Almacenamiento:This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -70℃. Preservative-Free.
Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Other IL1F6 Antibody Products
IL-1F6 Fondo

Interleukin-1 family member 6 (IL-1F6), also known as interleukin 36, alpha (IL36A), is a pro-inflammatory cytokine which plays an important role in innate and adaptive immunity. IL-1F6 activates MAPK and NF-kB pathways and is produced by many different cells. This cytokine is a family member of interleukin-1 (IL-1) and plays an important role in the pathophysiology of several diseases. It has been reported that IL-1F6 and IL-1F8, in addition to IL-1F9, activate the pathway leading to NF-kappaB in an IL-1Rrp2-dependent manner in Jurkat cells as well as in multiple other human and mouse cell lines. Activation of the pathway leading to NF-kappaB by IL-1F6 and IL-1F8 follows a similar time course to activation by IL-1beta, suggesting that signaling by the novel family members occurs through a direct mechanism. In a mammary epithelial cell line, NCI/ADR-RES, which naturally expresses IL-1Rrp2, all three cytokines signal without further receptor transfection. IL-1Rrp2 antibodies block activation of the pathway leading to NF-kappaB by IL-1F6, IL-1F8, and IL-1F9 in both Jurkat and NCI/ADR-RES cells. Thus IL-1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP.

Human IL-1F6 Referencias
  • Tripodi D, et al. (2012) IL-36 a new member of the IL-1 family cytokines. J Biol Regul Homeost Agents. 26(1):7-14.
  • Towne JE, et al. (2004) Interleukin (IL)-1F6, IL-1F8, and IL-1F9 signal through IL-1Rrp2 and IL-1RAcP to activate the pathway leading to NF-kappaB and MAPKs. J Biol Chem. 279(14): 13677-88.
  • Kumar S, et al. (2000) Identification and initial characterization of four novel members of the interleukin-1 family. J Biol Chem. 275(14): 10308-14.
  • Product nameProduct name
    Size / Price
    Catálogo: 10607-RP01-100
    Precio de lista: 
    Precio:      (You Save: )
    Tamaño:
    100 µg
    200 µg
    Cantidad:+-
    DisponibilidadIn Stock
    Bulk Discount RequiryAñadir a carro
    Contact Us
    Imágenes
        Artículos vistos recientemente
          All information of our products is subject to change without notice. Please refer to COA enclosed in shipped package for the newest information.
          Nota: Todos los productos son "PARA SU USO ÚNICAMENTE EN INVESTIGACIÓN Y NO INDICADOS PARA SU USO DIAGNÓSTICO O TERAPÉUTICO"