APLP1, also known as amyloid-like protein 1, is a member of the highly conserved amyloid precursor protein gene family. APLP1 is a membrane-associated glycoprotein that is cleaved by secretases in a manner similar to amyloid beta A4 precursor protein cleavage. APLP1, together with APLP2, are important modulators of glucose. APLP1 may also play a role in synaptic maturation during cortical development. Alternatively spliced transcript variants encoding different isoforms have been described. APLP1 also is a mammalian homologue of amyloid precursor protein (APP). APP is a type I membrane protein that is genetically linked to Alzheimer's disease.
amyloid beta (A4) precursor-like protein 1
- Wasco W. et al., 1993, Genomics. 15 (1): 237-9.
- Needham BE. et al., 2008, J Pathol. 215 (2): 155-63.
- Bayer TA. et al., 2000, Mol Psychiatry. 4 (6): 524-8.
- Lee S. et al., 2011, Biochemistry. 50 (24): 5453-64.