Podoplanin cDNA ORF Clone, Mouse, untagged General Information
Full length Clone DNA of Mouse podoplanin.
Enhanced CMV promoter
T7( 5' TAATACGACTCACTATAGGG 3' )
BGH( 5' TAGAAGGCACAGTCGAGG 3' )
The plasmid is confirmed by full-length sequencing.
Antibiotic in E.coli
Antibiotic in Mammalian cell
Stable or Transient mammalian expression
Storage & Shipping
Each tube contains lyophilized plasmid.
The lyophilized plasmid can be stored at ambient temperature for three months.
**Sino Biological guarantees 100% sequence accuracy of all synthetic DNA constructs we deliver, but we do not guarantee protein expression in your experimental system. Protein expression is influenced by many factors that may vary between experiments or laboratories.**
Podoplanin cDNA ORF Clone, Mouse, untagged Alternative Names
Gp38 cDNA ORF Clone, Mouse;OTS-8 cDNA ORF Clone, Mouse;RANDAM-2 cDNA ORF Clone, Mouse;T1-alpha cDNA ORF Clone, Mouse;T1a cDNA ORF Clone, Mouse;T1alpha cDNA ORF Clone, Mouse
Podoplanin Background Information
Podoplanin, also known as PDPN, is a type-I integral membrane glycoprotein with diverse distribution in human tissues. The physiological function of this protein may be related to its mucin-type character. The homologous protein in other species has been described as a differentiation antigen and influenza-virus receptor. The specific function of this protein has not been determined. Alternatively spliced transcript variants encoding different isoforms have been identified.PDPN is a mucin-type glycoprotein negatively charged by extensive O-glycosylation and a high content of sialic acid, which expresses the adhesive property. It is selectively expressed in lymphatic endothelium as well as lymphangiomas, Kaposi sarcomas, and in a subset of angiosarcomas with probable lymphatic differentiation. PDPN may contribute to form odontoblastic fiber or function as the anchorage to the tooth development and in proliferating epithelial cells of cervical loop and apical bud. The intensity of podoplanin expression is negatively correlated with the expression of CD34 and factor VIII. Podoplanin would be useful as a diagnostic marker for epithelioid hemangioendothelioma in liver tumors.
Immune Checkpoint Immunotherapy Cancer Immunotherapy Targeted Therapy
Kimura, N. et al., 2005, Pathol Int. 55 (2): 83-86. Ordóñez, N.G., 2006, Adv Anat Pathol. 13 (2): 83-88. Wicki, A. et al., 2007, Br. J. Cancer. 96 (1): 1-5. Fujii,T. et al., 2008, Mod Pathol. 21 (2): 125-130. Sawa,Y. et al., 2008, Acta Histochem Cytochem. 41 (5):121-126. Kaddu, S. et al., 2009, Am J Dermatopathol. 31 (2): 137-139.