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Rat Peroxiredoxin 2/PRDX2 clonación del ADN o clonación génica(Vector de expresión)

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Rat PRDX2 Información de producto de clon de cDNA
Gene_bank_ref_id:BC058481.1
Tamaño de cDNA:597bp
Descripción de cDNA:Full length Clone DNA of Rattus norvegicus peroxiredoxin 2.
Sinónimo de gen:Tdpx1
Especie:Rat
Vector:pUC19 Vector
Plasmid:cpUC19-ratPrdx2
Sitio de restricción:
Secuencia de etiquetas:
Descripción de la secuencia:Identical with the Gene Bank Ref. ID sequence except for the point mutation: 474C>T not causing the amino acid variation.
Sequencing primers:M13-47 and RV-M
Promoter:
Application:
Antibiotic in E.coli:Ampicilin
Antibiotic in mammalian cell:
Shipping_carrier:Each tube contains lyophilized plasmid.
Almacenamiento:The lyophilized plasmid can be stored at room temperature for three months.
Rat PRDX2 Gene Plasmid Map
Rat PRDX2 Gene cDNA Clone (full-length ORF Clone)
pUC19 vector Vector Information:

pUC19 is a small, high-copy number E. coli plasmid cloning vector, of which multiple cloning sites as shown below. The molecule is a small double-stranded circle, 2686 base pairs in length. pUC19 encodes the N-terminal fragment of b-galactosidase (lacZa), which allows for blue/white colony screening (i.e., a-complementation), as well as a pUC origin of replication.

pUC19 vector Usage Suggestion:

The coding sequence can be amplified by PCR with M13-47 and RV-M primers.

Vector Sequence Download
Rat Peroxiredoxin 2/PRDX2 clonación del ADN o clonación génica(Vector de expresión) on other vectors
Rat Peroxiredoxin 2/PRDX2 clonación del ADN o clonación génica(vector de clonación), C-GFPSpark EtiquetaRG80710-ACG$225
Rat Peroxiredoxin 2/PRDX2 clonación del ADN o clonación génica(vector de clonación), C-OFPSpark EtiquetaRG80710-ACR$225
Rat Peroxiredoxin 2/PRDX2 clonación del ADN o clonación génica(vector de clonación), N-GFPSpark EtiquetaRG80710-ANG$225
Rat Peroxiredoxin 2/PRDX2 clonación del ADN o clonación génica(vector de clonación), N-OFPSpark EtiquetaRG80710-ANR$225
Rat Peroxiredoxin 2/PRDX2 clonación del ADN o clonación génica(vector de clonación), C-Flag EtiquetaRG80710-CF$195
Rat Peroxiredoxin 2/PRDX2 clonación del ADN o clonación génica(vector de clonación), C-His EtiquetaRG80710-CH$195
Rat Peroxiredoxin 2/PRDX2 clonación del ADN o clonación génica(vector de clonación), C-Myc EtiquetaRG80710-CM$195
Rat Peroxiredoxin 2/PRDX2 clonación del ADN o clonación génica(vector de clonación), C-HA EtiquetaRG80710-CY$195
Rat Peroxiredoxin 2/PRDX2 clonación del ADN o clonación génica(vector de clonación), N-Flag EtiquetaRG80710-NF$195
Rat Peroxiredoxin 2/PRDX2 clonación del ADN o clonación génica(vector de clonación), N-His EtiquetaRG80710-NH$195
Rat Peroxiredoxin 2/PRDX2 clonación del ADN o clonación génica(vector de clonación), N-Myc EtiquetaRG80710-NM$195
Rat Peroxiredoxin 2/PRDX2 clonación del ADN o clonación génica(vector de clonación), N-HA EtiquetaRG80710-NY$195
Rat Peroxiredoxin 2/PRDX2 clonación del ADN o clonación génica(Vector de expresión)RG80710-U$75
Rat Peroxiredoxin 2/PRDX2 clonación del ADN o clonación génica(vector de clonación)RG80710-UT$195
 Más información sobre los vectores de expresión
Product nameProduct name
Fondo

Peroxiredoxin-2, also known as Natural killer cell-enhancing factor B, NKEF-B, Thiol-specific antioxidant protein, Thioredoxin peroxidase 1, Thioredoxin-dependent peroxide reductase 1, PRDX2 and NKEFB, is a cytoplasm protein which belongs to the ahpC / TSA family. Peroxiredoxin-2 / PRDX2 contains one thioredoxin domain. Peroxiredoxin-2 / PRDX2 is involved in redox regulation of the cell. It reduces peroxides with reducing equivalents provided through the thioredoxin system. Peroxiredoxin-2 / PRDX2 is not able to receive electrons from glutaredoxin. It may play an important role in eliminating peroxides generated during metabolism. Peroxiredoxin-2 / PRDX2 might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H2O2.

The Peroxiredoxins / Prx are a family of peroxidases that can reduce H2O2 using an electron from thioredoxin (Trx) or other substances. The mammalian Peroxiredoxins / Prx family is divided into six groups ( PRDX1,PRDX2, PRDX3, PRDX4, PRDX5, PRDX6 ) on the basis of homology of amino acid sequences. They are located in the cytosol and play a role in the cell signaling system. All six mammalian peroxiredoxins are expressed in the lung. Peroxiredoxins / Prx is overexpressed in breast cancer tissues to a great extent suggesting that Peroxiredoxins / Prx has a proliferative effect and may be related to cancer development or progression.

Referencias
  • Cha M.-K., et al., 1995,  Biochem. Biophys. Res. Commun. 217:900-7.
  • Noh,D.Y. et al., 2001, Anticancer Res. 21 (3B): 2085-90.
  • Chevallet M., et al., 2003, J. Biol. Chem. 278:37146-53.
  • Schremmer,B. et al., 2007, Subcell Biochem. 44 :317-44.
  • Gauci S., et al., 2009, Anal. Chem. 81:4493-501.
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