Anti-Pentraxin 3 Antibody (Rabbit Monoclonal antibody) General Information
Anti-Pentraxin 3 Antibody
Reacts with: Human
Human Pentraxin 3
Recombinant Human PTX3 / Pentraxin 3 / TSG-14 protein (Catalog#12082-H08H)
This antibody was obtained from a rabbit immunized with purified, recombinant Human PTX3 / Pentraxin 3 / TSG-14 (rh PTX3 / Pentraxin 3 / TSG-14; Catalog#12082-H08H; NP_002843.2; Met 1-Ser 381).
Monoclonal Rabbit IgG Clone #029
0.2 μm filtered solution in PBS with 5% trehalose
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-Pentraxin 3 Antibody (Rabbit Monoclonal antibody) Validated Applications
|| 1-2 μg/mL
**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********
Anti-Pentraxin 3 Antibody Alternative Names
Anti-PTX3 Antibody;Anti-TNFAIP5 Antibody;Anti-TSG-14 Antibody
Pentraxin 3 Background Information
Pentraxin-related protein PTX3, also known as Tumor necrosis factor alpha-induced protein 5, Tumor necrosis factor-inducible gene 14 protein, TSG-14, PTX3 and TNFAIP5, is a secreted protein which contains one pentaxin domain. PTX3 plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility. Pentraxins are a family of evolutionarily conserved multifunctional pattern-recognition proteins characterized by a cyclic multimeric structure. Based on the primary structure of the subunit, the pentraxins are divided into two groups: short pentraxins and long pentraxins. C-reactive protein (CRP) and serum amyloid P-component (SAP) are the two short pentraxins. The prototype protein of the long pentraxin group is pentraxin 3 (PTX3). CRP and SAP are produced primarily in the liver in response to IL-6, while PTX3 is produced by a variety of tissues and cells and in particular by innate immunity cells in response to proinflammatory signals and Toll-like receptor (TLR) engagement. PTX3 is essential in female fertility by acting as a nodal point for the assembly of the cumulus oophorus hyaluronan-rich extracellular matrix. PTX3 interacts with several ligands, including growth factors, extracellular matrix components and selected pathogens, playing a role in complement activation and facilitating pathogen recognition by phagocytes, acting as a predecessor of antibodies. PTX3 may also contribute to the pathogenesis of atherosclerosis.
Rolph,M.S. et al., 2002, Arterioscler Thromb Vasc Biol. 22 (5):e10-4. Mantovani A., et al., 2003, Vaccine. 21:S43-S47. Luchetti,M.M. et al., 2004, Clin Exp Rheumatol. 22 (3):S66-72. Mantovani, A. et al., 2006, Vascul Pharmacol. 45 (5):326-30. Inforzato A., et al., 2008, J. Biol. Chem. 283:10147-61.