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PTX3 / Pentraxin 3 / TSG-14 Anticuerpo, Mabs de conejo

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    Humano PTX3 Información de producto de anticuerpo
    Inmunogen:Recombinant Human PTX3 / Pentraxin 3 / TSG-14 protein (Catalog#12082-H08H)
    Clone ID:029
    Tipo de Ig:Rabbit IgG
    Concentración:
    Endotoxina:
    Formulación:0.2 μm filtered solution in PBS with 5% trehalose
    Preparación:This antibody was obtained from a rabbit immunized with purified, recombinant Human PTX3 / Pentraxin 3 / TSG-14 (rh PTX3 / Pentraxin 3 / TSG-14; Catalog#12082-H08H; NP_002843.2; Met 1-Ser 381).
    Other PTX3 Antibody Products
    Reactividad: Human  
    Aplicación: ELISA  
      12082-RP02-50
      12082-RP02-200
      12082-RP02-100
      50 µg 
      200 µg 
      100 µg 
      Add to Cart
      Reactividad: Human  
      Aplicación: 
        12082-MM04-50
        12082-MM04-200
        12082-MM04-100
        12082-MM04-1
        50 µg 
        200 µg 
        100 µg 
        1 mg 
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        Reactividad: Human  
        Aplicación: ELISA  
          12082-RP01-400
          12082-RP01-200
          12082-RP01-100
          400 µg 
          200 µg 
          100 µg 
          Add to Cart
          Reactividad: Human  
          Aplicación: ELISA  
            12082-MM01-50
            12082-MM01-200
            12082-MM01-100
            50 µg 
            200 µg 
            100 µg 
            Add to Cart
            Reactividad: Human  
            Aplicación: ELISA  
              12082-R070-50
              12082-R070-100
              12082-R070-1
              50 µg 
              100 µg 
              1 mg 
              Add to Cart
              PTX3/Pentraxin 3/TSG-14 Fondo

              Pentraxin-related protein PTX3, also known as Tumor necrosis factor alpha-induced protein 5, Tumor necrosis factor-inducible gene 14 protein, TSG-14, PTX3 and TNFAIP5, is a secreted protein which contains one pentaxin domain. PTX3 plays a role in the regulation of innate resistance to pathogens, inflammatory reactions, possibly clearance of self-components and female fertility. Pentraxins are a family of evolutionarily conserved multifunctional pattern-recognition proteins characterized by a cyclic multimeric structure. Based on the primary structure of the subunit, the pentraxins are divided into two groups: short pentraxins and long pentraxins. C-reactive protein (CRP) and serum amyloid P-component (SAP) are the two short pentraxins. The prototype protein of the long pentraxin group is pentraxin 3 (PTX3). CRP and SAP are produced primarily in the liver in response to IL-6, while PTX3 is produced by a variety of tissues and cells and in particular by innate immunity cells in response to proinflammatory signals and Toll-like receptor (TLR) engagement. PTX3 is essential in female fertility by acting as a nodal point for the assembly of the cumulus oophorus hyaluronan-rich extracellular matrix. PTX3 interacts with several ligands, including growth factors, extracellular matrix components and selected pathogens, playing a role in complement activation and facilitating pathogen recognition by phagocytes, acting as a predecessor of antibodies. PTX3 may also contribute to the pathogenesis of atherosclerosis.

              Humano PTX3/Pentraxin 3/TSG-14 Referencias
            • Rolph,M.S. et al., 2002, Arterioscler Thromb Vasc Biol. 22 (5):e10-4.
            • Mantovani A., et al., 2003, Vaccine. 21:S43-S47.
            • Luchetti,M.M. et al., 2004, Clin Exp Rheumatol. 22 (3):S66-72.
            • Mantovani, A. et al., 2006, Vascul Pharmacol. 45 (5):326-30.
            • Inforzato A., et al., 2008, J. Biol. Chem. 283:10147-61.
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