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TIM4 / TIMD4 Anticuerpo, Mabs de conejo

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    Humano TIMD4 Información de producto de anticuerpo
    Inmunogen:Recombinant Human TIM4 protein (Catalog#12161-H08H)
    Clone ID:101
    Tipo de Ig:Rabbit IgG
    Concentración:
    Endotoxina:
    Formulación:0.2 μm filtered solution in PBS with 5% trehalose
    Preparación:This antibody was obtained from a rabbit immunized with purified, recombinant Human TIM4 (rh TIM4; Catalog#12161-H08H; AAH08988.1; Met1-Leu315).
    Other TIMD4 Antibody Products
    TIMD4 Fondo

    A type I transmembrane protein called TIM4 (T-cell immunoglobulin- and mucin-domain-containing molecule; also known as TIMD4), which belongs to the immunoglobulin superfamily and TIM family. TIM4 is involved in regulating T-cell proliferation and lymphotoxin signaling. It is a ligand for HAVCR1/TIMD1. Recent reports indicate that dendritic cell (DC)-derived T-cell immunoglobulin and mucin domain molecule (TIM)-4, which is expressed on dendritic cells and macrophages, plays an important role in the initiation of T(H)2 polarization. TIM4 bound apoptotic cells by recognizing phosphatidylserine via its immunoglobulin domain. The expression of TIM4 in fibroblasts enhanced their ability to engulf apoptotic cells. TIM4 is phosphatidylserine receptor for the engulfment of apoptotic cells, and may also be involved in intercellular signalling in which exosomes are involved. Modulation of TIM4 production in dendritic cells (DCs) represents a novel therapeutic approach for the treatment of peanut allergy. The interaction of TIM1/TIM4 played a critical role in sustaining the polarization status of Th2 cells in allergic rhinitis (AR) patients. Cross-linking FcgammaRI by antigen/IgG complexes increased the production of TIM4 by dendritic cells via upregulating tumor necrosis factor-alpha in DCs. Specific immunotherapy (SIT) suppresses the skewed Th2 responses via disrupting the interaction of TIM1/TIM4 in antigen-specific Th2 cells.

    Humano TIMD4 Referencias
  • Miyanishi M, et al. (2007) Identification of Tim4 as a phosphatidylserine receptor. Nature. 450(7168): 435-9.
  • Feng BS, et al. (2008) Disruption of T-cell immunoglobulin and mucin domain molecule (TIM)-1/TIM4 interaction as a therapeutic strategy in a dendritic cell-induced peanut allergy model. J Allergy Clin Immunol. 122(1): 55-61.
  • Cai PC, et al. (2009) Association of TIM4 promoter polymorphism -1419GA with childhood asthma in a Chinese Han population. Tissue Antigens. 74(1): 11-6.
  • Zhao CQ, et al. (2010) Specific immunotherapy suppresses Th2 responses via modulating TIM1/TIM4 interaction on dendritic cells. Allergy. 65(8): 986-95.
  • Product nameProduct name
    Size / Price
    Catálogo: 12161-R101-50
    Precio de lista: 
    Precio:      (You Save: )
    Tamaño:
    50 µg
    100 µg
    Cantidad:+-
    DisponibilidadIn Stock
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    Datasheet & Documentation

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