Anti-TRXR1 Antibody

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Anti-TRXR1 Antibody (Rabbit Polyclonal antibody) General Information

Product name
Anti-TRXR1 Antibody
Validated applications
ELISA
Species reactivity
Reacts with: Human
Specificity
Human TRXR1
Immunogen
Recombinant Human TXNRD1 / GRIM-12 protein (Catalog#13093-H07E)
Preparation
Produced in rabbits immunized with purified, recombinant Human TXNRD1 / GRIM-12 (rh TXNRD1 / GRIM-12; Catalog#13093-H07E; Q16881-1; Tyr 161-Cys647). Total IgG was purified by Protein A affinity chromatography.
Source
Polyclonal Rabbit IgG
Purification
Protein A
Formulation
0.2 μm filtered solution in PBS with 5% trehalose
Conjugate
Unconjugated
Form
Liquid
Shipping
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
Storage
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Avoid repeated freeze-thaw cycles.

Anti-TRXR1 Antibody (Rabbit Polyclonal antibody) Validated Applications

Application Dilution
ELISA 1:1000-1:2000
Please Note: Optimal concentrations/dilutions should be determined by the end user.

Anti-TRXR1 Antibody: Alternative Names

Anti-GRIM-12 Antibody; Anti-TR Antibody; Anti-TR1 Antibody; Anti-TRXR1 Antibody; Anti-TXNR Antibody

TRXR1 Background Information

Thioredoxin reductase 1 (TXNRD1) which is a selenocysteine-containing protein is overexpressed in many malignancies. TXNRD1 plays a key role in regulating cell growth and transformation, and protects cells against oxidative damage. We investigated the association between TXNRD1 polymorphisms and ATDH susceptibility. Moreover, TXNRD1 is an essential selenium-containing enzyme involved in detoxification of reactive oxygen species (ROS) and redox signaling. And genetic variations in TXNRD1 favor the development of Drug-induced liver injury (DILI), which is the most common adverse drug reaction.
Full Name
thioredoxin reductase 1
References
  • Gasdaska P.Y., et al., 1995, FEBS Lett. 373:5-9.
  • Rundloef A.-K., et al., 2004, Free Radic. Biol. Med. 36:641-656.
  • Rikova K., et al., 2007, Cell 131:1190-1203.
  • Fritz-Wolf K., et al., 2007, J. Mol. Biol. 370:116-127.
  • Choudhary C., et al., 2009, Science 325:834-840.
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