Anti-TRXR1 Antibody (Rabbit Polyclonal antibody) General Information
Reacts with: Human
Recombinant Human TXNRD1 / GRIM-12 protein (Catalog#13093-H07E)
Produced in rabbits immunized with purified, recombinant Human TXNRD1 / GRIM-12 (rh TXNRD1 / GRIM-12; Catalog#13093-H07E; Q16881-1; Tyr 161-Cys647). Total IgG was purified by Protein A affinity chromatography.
Polyclonal Rabbit IgG
0.2 μm filtered solution in PBS with 5% trehalose
This antibody is shipped as liquid solution at ambient temperature. Upon receipt, store it immediately at the temperature recommended below.
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free. Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Anti-TRXR1 Antibody (Rabbit Polyclonal antibody) Validated Applications
**********Please Note: Optimal concentrations/dilutions should be determined by the end user.**********
Anti-TRXR1 Antibody Alternative Names
Anti-GRIM-12 Antibody;Anti-TR Antibody;Anti-TR1 Antibody;Anti-TRXR1 Antibody;Anti-TXNR Antibody
TRXR1 Background Information
Thioredoxin reductase 1 (TXNRD1) which is a selenocysteine-containing protein is overexpressed in many malignancies. TXNRD1 plays a key role in regulating cell growth and transformation, and protects cells against oxidative damage. We investigated the association between TXNRD1 polymorphisms and ATDH susceptibility. Moreover, TXNRD1 is an essential selenium-containing enzyme involved in detoxification of reactive oxygen species (ROS) and redox signaling. And genetic variations in TXNRD1 favor the development of Drug-induced liver injury (DILI), which is the most common adverse drug reaction.
thioredoxin reductase 1
Gasdaska P.Y., et al., 1995, FEBS Lett. 373:5-9. Rundloef A.-K., et al., 2004, Free Radic. Biol. Med. 36:641-656. Rikova K., et al., 2007, Cell 131:1190-1203. Fritz-Wolf K., et al., 2007, J. Mol. Biol. 370:116-127. Choudhary C., et al., 2009, Science 325:834-840.