C6 Protein

C6 Protein Overview

C6 reagents

DiScipio and Hugli (1989) isolated a cDNA encoding C6 from a human liver cDNA library. The deduced C6 protein contains 934 amino acids, including a 21-amino acid N-terminal signal sequence and 2 N-glycosylation sites. The mature 913-amino acid C6 protein shares 29% amino acid identity with C7 (217070), and 55 of 56 cysteines in C7 match those in C6. The C6 polypeptide chain is cross-linked by 32 disulfide bonds, and most cysteines are located in short, discrete segments that exhibit homology with a variety of proteins, including thrombospondin (see 188060), low density lipoprotein receptor (LDLR; 606945), epidermal growth factor (EGF; 131530), and complement factors H (CFH; 134370) and I (CFI; 217030). Independently, Haefliger et al. (1989) cloned C6 from a human liver cDNA library. They determined that the mature C6 protein shares 33.5% amino acid identity with C7, including conservation of all 56 cysteines.

C6 protein family

Belongs to the complement C6/C7/C8/C9 family.

C6 protein name

Recommended name
Complement component C6

C6 Protein Sequence

Species Human C6 protein
Length 934
Mass (Da) 104786
Sequence Human C6 protein sequence
Species
Length
Mass (Da)
Sequence
Species Rat C6 protein
Length 934
Mass (Da) 105114
Sequence Rat C6 protein sequence

C6 Protein Molecular Weight & PI

Complement component C6 precursor Homo sapiens (Human).

The parameters have been computed for the following feature

FT CHAIN 22-934 Complement component C6.

Molecular weight (Da)

102412.18

Theoretical pI

6.17

C6 Protein Structure

Crystal Structure of human Complement Component C6
Deposited
2011-07-27   Released:  2012-02-01
Deposition Author(s)
Aleshin, A.E., Stec, B., Bankston, L.A., DiScipio, R.G., Liddington, R.C.
Organism(s)
Homo sapiens
Experimental Data Snapshot
Method
X-RAY DIFFRACTION
Resolution
2.8690 Å
R-Value Free
0.276
R-Value Work
0.222
3T5O From PDB

Human C6 protein Secondary structure

C6 Protein Interaction

Recombinant C6 Protein Feature

C6 Protein, Human, Recombinant (His Tag)

High Purity
> 90 % as determined by SDS-PAGE
Low Endotoxin
< 1.0 EU per μg of the protein as determined by the LAL method

Recombinant C6 protein citations

Title
Sublytic C5b-9 induces IL-6 and TGF-β1 production by glomerular mesangial cells in rat Thy-1 nephritis through p300-mediated C/EBPβ acetylation
Year
2014
Author
Zhang, J;Li, Y;Shan, K;Wang, L;Qiu, W;Lu, Y;Zhao, D;Zhu, G;He, F;Wang, Y;
Journal
FASEB J.
Title
Sublytic C5b-9 triggers glomerular mesangial cell apoptosis in rat Thy-1 nephritis via Gadd45 activation mediated by Egr-1 and p300-dependent ATF3 acetylation
Year
2016
Author
He, F;Zhou, M;Yu, T;Zhao, D;Zhang, J;Qiu, W;Lu, Y;Liu, Y;Wang, L;Wang, Y;
Journal
J Mol Cell Biol
Title
Sublytic C5b-9 Induces Glomerular Mesangial Cell Apoptosis through the Cascade Pathway of MEKK2-p38 MAPK-IRF-1-TRADD-Caspase 8 in Rat Thy-1 Nephritis
Year
2017
Author
Zhu, G;Qiu, W;Li, Y;Zhao, C;He, F;Zhou, M;Wang, L;Zhao, D;Lu, Y;Zhang, J;Liu, Y;Yu, T;Wang, Y;
Journal
J. Immunol
Title
Sublytic C5b-9 Induces Glomerular Mesangial Cell Apoptosis Through miR-3546/SOX4/Survivin Axis in Rat Thy-1 Nephritis
Year
2018
Author
Yao, C;He, F;Liu, L;Zhang, Z;Zhao, C;Qiu, W;Zhao, D;Zhang, J;Xie, M;Gong, Y;Yu, T;Xia, L;Qian, B;Wang, Y;
Journal
Cell. Physiol. Biochem.
Title
Sublytic C5b-9 induces proliferation of glomerular mesangial cells via ERK5/MZF1/RGC-32 axis activated by FBXO28-TRAF6 complex
Year
2019
Author
Yu, T;Wang, L;Zhao, C;Qian, B;Yao, C;He, F;Zhu, Y;Cai, M;Li, M;Zhao, D;Zhang, J;Wang, Y;Qiu, W;
Journal
J. Cell. Mol. Med.

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