GBP2 cDNA ORF Clone, Human, C-DDK (Flag®) tag

GBP-2 belongs to the guanylate-binding protein (GBP) family. GBPs are characterized by their ability to specifically bind guanine nucleotides (GMP, GDP, and GTP). As GTPases induced by IFN-gamma (Interferon-inducible GTPase), they are key to the protective immunity against microbial and viral pathogens. GBP-2 is a GTPase that converts GTP to GDP and GMP. It binds GTP, GDP and GMP. GBP-2 hydrolyzes GTP very efficiently. GDP rather than GMP is the major reaction product. GBP-2 is induced by interferons that have antiviral effects and inhibit tumor cell proliferation.

guanylate binding protein 2

• Cancer>>Signal Transduction>>Second Messenger>>Nucleotide Messenger>>GTP
• Immunology>>Innate Immunity>>Cytokine>>Interferons

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