IL17: IL17 Protein | IL17 Antibody

IL17 Gene family

IL17 Background

IL17, also known as IL17a, is a cytokine belongs to the IL-17 family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophages, dendritic cells) and adaptive (T- and B-cells) immune systems. The IL-17 family of cytokines includes six members, IL-17/IL-17A, IL-17B, IL-17C, IL-17D, IL-17E/IL-25, and IL-17F, which are produced by multiple cell types. IL-17 regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2 (PTGS2/COX-2), as well as enhance the production of nitric oxide (NO). High levels of IL-17 are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis.

Reference for IL17

  • Andoh A, et al. (2002) IL-17 selectively down-regulates TNF-alpha-induced RANTES gene expression in human colonic subepithelial myofibroblasts. J Immunol. 169(4):1683-7.
  • Kotake S, et al. (1999) IL-17 in synovial fluids from patients with rheumatoid arthritis is a potent stimulator of osteoclastogenesis. J Clin Invest. 103(9):1345-52.
  • Laan M, et al. (1999) Neutrophil recruitment by human IL-17 via C-X-C chemokine release in the airways. J Immunol. 162(4):2347-52.
  • Shin HC, et al. (1999) Regulation of IL-17, IFN-gamma and IL-10 in human CD8(+) T cells by cyclic AMP-dependent signal transduction pathway. Cytokine. 10(11):841-50.

IL17 Protein

IL17 protein function

Ligand for IL17RA and IL17RC (PubMed:17911633). The heterodimer formed by IL17A and IL17F is a ligand for the heterodimeric complex formed by IL17RA and IL17RC (PubMed:18684971). Involved in inducing stromal cells to produce proinflammatory and hematopoietic cytokines (PubMed:8676080). {ECO:0000269|PubMed:17911633, ECO:0000269|PubMed:18684971, ECO:0000269|PubMed:8676080}.

IL17 protein expression

Tissue specificity

Restricted to activated memory T-cells.

IL17 protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    155.00
  • Mass (Da)
    17.00

IL17 Antibody

There are 8 IL17 antibodies which are validated in multiple tissues with various applications, including Neutralization, ELISA, ELISA(Cap), ELISA(Det). There are 1 IL17 antibody for Neutralization, 5 IL17 antibody for ELISA, 2 IL17 antibody for ELISA(Cap), 1 IL17 antibody for ELISA(Det). Among all these IL17 antibodies, there are 5 anti-IL17 mouse monoclonal antibodies , 2 anti-IL17 rabbit polyclonal antibodies , 1 anti-IL17 rabbit monoclonal antibodies . All the IL17 anbodies are produced in house and all are in stock. IL17 antibody customerized service is available.

IL17 Gene

IL17A gene / cDNA is a protein-coding gene which located on 6p12.2. The IL17A gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, and frog.141 organisms have orthologs with human gene IL17A.