14-3-3 epsilon: 14-3-3 epsilon Protein | 14-3-3 epsilon Antibody

14-3-3 epsilon Gene family

14-3-3 epsilon Background

YWHAE, also known as 14-3-3 epsilon, mediate signal transduction by binding to phosphoserine-containing proteins. 14-3-3 epsilon / YWHAE is a member of the 14-3-3 proteins family. 14-3-3 proteins are a group of highly conserved proteins that are involved in many vital cellular processes such as metabolism, protein trafficking, signal transduction, apoptosis and cell cycle regulation. 14-3-3 proteins are mainly localized in the synapses and neuronal cytoplasm, and seven isoforms have been identified in mammals. This family of proteins was initially identified as adaptor proteins which bind to phosphoserine-containing motifs. Binding motifs and potential functions of 14-3-3 proteins are now recognized to have a wide range of functional relevance. 14-3-3 epsilon / YWHAE is found in both plants and mammals, and this protein is 1% identical to the mouse ortholog. YWHAE interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. 14-3-3 epsilon / YWHAE is implicated in the regulation of a large spectrum of both general and specialized signaling pathways. 14-3-3 epsilon / YWHAE Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. This Binding generally results in the modulation of the activity of the binding partner.

Reference for 14-3-3 epsilon

  • Ikeda M, et al. (2008) Identification of YWHAE, a gene encoding 14-3-3epsilon, as a possible susceptibility gene for schizophrenia. Hum Mol Genet. 17(20): 3212-22.
  • Mignon-Ravix C, et al. (2010) Deletion of YWHAE in a patient with periventricular heterotopias and pronounced corpus callosum hypoplasia. J Med Genet. 47(2): 132-6.
  • Nagamani SC, et al. (2009) Microdeletions including YWHAE in the Miller-Dieker syndrome region on chromosome 17p13.3 result in facial dysmorphisms, growth restriction, and cognitive impairment. J Med Genet. 46(12): 825-33.

14-3-3 epsilon Protein

14-3-3 epsilon protein function

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner (By similarity). Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm (PubMed:12917326). {ECO:0000250|UniProtKB:P62261, ECO:0000269|PubMed:12917326}.

14-3-3 epsilon protein sequence

This sequence information is just for reference only.From Uniport

  • Length
    255.00
  • Mass (Da)
    29.00

14-3-3 epsilon Antibody

There are 3 14-3-3 epsilon antibodies which are validated in multiple tissues with various applications, including ELISA, WB, ICC/IF, IP. There are 2 14-3-3 epsilon antibody for ELISA, 2 14-3-3 epsilon antibody for WB, 2 14-3-3 epsilon antibody for ICC/IF, 2 14-3-3 epsilon antibody for IP. Among all these 14-3-3 epsilon antibodies, there are 1 anti-14-3-3 epsilon mouse monoclonal antibodies , 2 anti-14-3-3 epsilon rabbit polyclonal antibodies . All the 14-3-3 epsilon anbodies are produced in house and all are in stock. 14-3-3 epsilon antibody customerized service is available.

14-3-3 epsilon Gene

YWHAE gene / cDNA is a protein-coding gene which located on 17p13.3. The YWHAE gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog.215 organisms have orthologs with human gene YWHAE.